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KMID : 0369819970270010071
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Jorunal of Korean Pharmaceutical Sciences
1997 Volume.27 No. 1 p.71 ~ p.77
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Fabrication and Characterization of Flurbiprofen loaded Chitosan Beads for Periodontal Regeneration
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이수진/Rhee SJ
박윤정/이승진/정종평/Park YJ/Lee SJ/Chung CP
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Abstract
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With the aim of improving periodontal regeneration efficacy, as a biodegradable local drug delivery device, drug releasing chitosan beads were prepared. Chitosan beads were prepared through the formation of intermolecular or intramolecular ionic interaction bewteen chitosan and sodium tripolyphosphate and were loaded with flurbiprofen. The mean diameter of the beads was 250μm. Drug loading efficiency was improved by regulating the pH of tripolyphosphate solution. The drug release kinetics mainly depended upon the hydrophobic properties of the flurbiprofen, that is, the release of flurbiprofen showed initial burst with rapid release for the first day followed by a levelling off of the release rate. However, the release rate could be controlled by the formulation factor including the pH, concentration of the tripolyphosphate solution, gelation time, drug contents. From these results, flurbiprofen loaded chitosan beads were anticipated as biodegradable local drug delivery devices for periodontal regeneneration.
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KEYWORD
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Periodontal regeneration, Chitosan bead, Controlled release, Flurbiprofen, Biodegradable local drug delivery
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